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Article

NF-&#954; B and Rheumatic Diseases

1 Dec 2006

Abstract excerpt

NF-kappaB is an inducible transcription factor that is controlled by the signal activation cascades. NF-kappaB controls a number of genes involved in immuno-inflammatory responses, cell cycle progression, inhibition of apoptosis, and cell adhesion, thus promoting chronic inflammatory responses. In fact, NF-kappaB is constitutively activated in some rheumatic conditions such as rheumatoid arthritis (RA) and...

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PMID: 17214582
DOI: 10.2174/187153006779025685

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