Article
Effect of siRNAs targeting the EGFR T790M mutation in a non-small cell lung cancer cell line resistant to EGFR tyrosine kinase inhibitors and combination with various agents.
Biochemical and biophysical research communications - 15 Feb 2013
Chen Gang, Kronenberger Peter, Teugels Erik, Umelo Ijeoma Adaku, De Grève Jacques
Abstract excerpt
The epidermal growth factor receptor (EGFR) is a validated therapeutic target in non-small cell lung cancer (NSCLC). However, some mutations confer resistance to current available agents, especially the frequently occurring T790M mutation. In the current study, we have examined, in a NSCLC cell line H1975 containing both L858R and T790M mutations, the effect of T790M-specific-siRNAs versus other...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.