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Survival Motor Neuron Affects Plastin 3 Protein Levels Leading to Motor Defects

11 Apr 2012

Abstract excerpt

The actin-binding protein plastin 3 (PLS3) has been identified as a modifier of the human motoneuron disease spinal muscular atrophy (SMA). SMA is caused by decreased levels of the survival motor neuron protein (SMN) and in its most severe form causes death in infants and young children. To understand the mechanism of PLS3 in SMA, we have analyzed pls3 RNA and protein in zebrafish smn mutants. We show that Pls3...

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PMID: 22496553
DOI: 10.1523/jneurosci.5808-11.2012

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