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Unliganded Thyroid Hormone Receptor Function: Amphibian Metamorphosis Got TALENs

21 Jan 2015

Abstract excerpt

Thyroid hormones (THs) are capital for development and cell homeostasis. THs act by regulating gene expression through TH receptors (TRs), which are transcription factors that belong to the nuclear receptors superfamily (1). THs and TRs are versatile players because they can not only up-regulate, but also down-regulate, gene expression in target cells. It is generally believed that TRs mediate both effects with...

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PMID: 25607994
DOI: 10.1210/en.2014-2016

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