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Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.

Chemico-biological interactions - 25 Feb 2013

Miura Takeshi, Taketomi Ayako, Nishinaka Toru, Terada Tomoyuki

Abstract excerpt

Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Additionally, cancer progression may be partly regulated by CBR1. In the present study, we screened more than 10 drugs for the induction of the...

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Identifiers

PMID: 23247010
DOI: 10.1016/j.cbi.2012.11.023

Genes

CBR1

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Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.PMID 23247010Read ↗

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