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Article

A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality.

Journal of child psychology and psychiatry, and allied disciplines - 1 Aug 2013

Grazioplene Rachael G, Deyoung Colin G, Rogosch Fred A, Cicchetti Dante

Abstract excerpt

BACKGROUND: The differential susceptibility hypothesis states that some genetic variants that confer risk in adverse environments are beneficial in normal or nurturing environments. The cholinergic system is promising as a source of susceptibility genes because of its involvement in learning and neural plasticity. The cholinergic receptor gene CHRNA4 has been linked to characteristics related to the personality...

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Identifiers

PMID: 23240931
DOI: 10.1111/jcpp.12031
PMCID: PMC3608843

Genes

CHRNA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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