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The effect of chemotherapy on telomere dynamics: clinical results and possible mechanisms

15 Dec 2012

Abstract excerpt

Telomeres are the chromosomal end components, and their length in hematopoietic stem cells correlates with the bone marrow proliferative reserve. There are few data regarding telomere dynamics in hematopoietic stem cells after exposure to chemotherapy. We show that the attrition of telomeres after cytotoxic treatment correlates with the intensity of chemotherapy. Using cytotoxic drugs with differential effects on...

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PMID: 23240911
DOI: 10.3109/10428194.2012.757765

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