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Article

Telomere shortening in hematopoietic stem cell transplantation: A potential mechanism for late graft failure?

1 Nov 2002

Abstract excerpt

Telomeres serve to maintain the structural integrity of chromosomes, yet each somatic cell division is associated with a decrease in telomere length. The cumulative decrease in telomere length can impose an upper limit for the number of cell divisions that can occur before a cell senesces. When studied in vitro with fibroblasts, this limit is referred to as the Hayflick limit and usually occurs after 40 to 80...

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Identifiers

PMID: 12463478
DOI: 10.1053/bbmt.2002.v8.abbmt080597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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