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Article

Ubiquitin/proteasome-rich particulate cytoplasmic structures (PaCSs) in the platelets and megakaryocytes of ANKRD26-related thrombo-cytopenia.

Thrombosis and haemostasis - 1 Feb 2013

Necchi Vittorio, Balduini Alessandra, Noris Patrizia, Barozzi Serena, Sommi Patrizia, di Buduo Christian, Balduini Carlo L, Solcia Enrico, Pecci Alessandro

Abstract excerpt

ANKRD26-related thrombocytopenia (ANKRD26-RT) is an autosomal-dominant thrombocytopenia caused by mutations in the 5'UTR of the ANKRD26 gene. ANKRD26-RT is characterised by dysmegakaryopoiesis and an increased risk of leukaemia. PaCSs are novel particulate cytoplasmic structures with selective immunoreactivity for polyubiquitinated proteins and proteasome that have been detected in a number of solid cancers, in...

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PMID: 23223974
DOI: 10.1160/TH12-07-0497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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