Article
Ubiquitin-proteasome-rich cytoplasmic structures in neutrophils of patients with Shwachman-Diamond syndrome.
Haematologica - 1 Jul 2012
Necchi Vittorio, Minelli Antonella, Sommi Patrizia, Vitali Agostina, Caruso Roberta, Longoni Daniela, Frau Maria Rita, Nasi Cristina, De Gregorio Fabiola, Zecca Marco, Ricci Vittorio, Danesino Cesare, Solcia Enrico
Abstract excerpt
BACKGROUND: Shwachman-Diamond syndrome is an autosomal recessive disorder in which severe bone marrow dysfunction causes neutropenia and an increased risk of leukemia. Recently, novel particulate cytoplasmic structures, rich in ubiquitinated and proteasomal proteins, have been detected in epithelial cells and neutrophils from patients with Helicobacter pylori gastritis and several epithelial neoplasms. DESIGN AND...
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