Article
Improving stability and understandability of genotype-phenotype mapping in Saccharomyces using regularized variable selection in L-PLS regression.
BMC bioinformatics - 8 Dec 2012
Mehmood Tahir, Warringer Jonas, Snipen Lars, Sæbø Solve
Abstract excerpt
BACKGROUND: Multivariate approaches have been successfully applied to genome wide association studies. Recently, a Partial Least Squares (PLS) based approach was introduced for mapping yeast genotype-phenotype relations, where background information such as gene function classification, gene dispensability, recent or ancient gene copy number variations and the presence of premature stop codons or frameshift...
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