Article
Comparison of the transduction efficiency of tyrosine-mutant adeno-associated virus serotype vectors in kidney.
Clinical and experimental pharmacology & physiology - 1 Jan 2013
Qi Yan F, Li Qiu H, Shenoy Vinayak, Zingler Michael, Jun Joo Y, Verma Amrisha, Katovich Michael J, Raizada Mohan K
Abstract excerpt
Gene therapy has a distinct potential to treat kidney diseases. However, the efficient transduction of a significant number of renal cells by viral vectors has been difficult to accomplish. Previous studies indicate that adeno-associated virus (AAV) can transduce renal cells with variable and suboptimal efficiency. Because new and innovative mutants of AAV are now available, we compared their efficacy in...
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