Article
Angiotensin 1-7 Overexpression Mediated by a Capsid-optimized AAV8 Vector Leads to Significant Growth Inhibition of Hepatocellular Carcinoma In vivo.
International journal of biological sciences - 1 Jan 2018
Mao Yingying, Pei Nana, Chen Xinglu, Chen Huiying, Yan Renhe, Bai Na, Li Andrew, Li Jinlong, Zhang Yanling, Du Hongyan, Chen Baihong, Sumners Colin, Wang Xuejun, Wang Shengqi, Li Hongwei
Abstract excerpt
Background: Angiotensin-(1-7) [Ang-(1-7)] has been identified to inhibit the growth of many types of tumor cells both in vitro and in vivo. However, the rapid degradation of Ang-(1-7) in vivo limits its clinical application. Adeno-associated virus (AAV) serotype-8 is a remarkable vector for long-term in vivo gene delivery. Method: This study was designed to investigate the effects of AAV-mediated Ang-(1-7)...
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