Article
An AAV2/5 vector enhances safety of gene transfer to the mouse salivary gland.
Journal of dental research - 1 Apr 2012
Geguchadze R N, Machen L, Zourelias L, Gallo P H, Passineau M J
Abstract excerpt
This study was designed to improve AAV-mediated gene transfer to the murine submandibular salivary glands. Our first aim was to utilize AAV pseudotype vectors, containing the genetic elements of the canonical AAV2, packaged within capsids of AAV serotypes 5, 8, and 9. Having determined that this pseudotyping increased the efficiency of gene transfer to the glands by several orders of magnitude, we next asked...
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