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Article

TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21

4 Dec 2012

Abstract excerpt

The biological function of Tripartite Motif 39 (TRIM39) remains largely unknown. In this study, we report that TRIM39 regulates the steady-state levels of p21 and is a pivotal determinant of cell fate. Ablation of TRIM39 leads to destabilization of p21 and increased G1/S transition in unperturbed cells. Furthermore, DNA damage-induced p21 accumulation is completely abolished in cells with depleted TRIM39. As a...

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PMID: 23213251
DOI: 10.1073/pnas.1214156110

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