Article
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.
Hepatology (Baltimore, Md.) - 1 Feb 2013
Adams Leon A, White Scott W, Marsh Julie A, Lye Stephen J, Connor Kristin L, Maganga Richard, Ayonrinde Oyekoya T, Olynyk John K, Mori Trevor A, Beilin Lawrence J, Palmer Lyle J, Hamdorf Jeffrey M, Pennell Craig E
Abstract excerpt
UNLABELLED: Genetic factors account for a significant proportion of the phenotypic variance of nonalcoholic fatty liver disease (NAFLD); however, very few predisposing genes have been identified. We aimed to (1) identify novel genetic associations with NAFLD by performing a genome-wide association study (GWAS), and (2) examine the biological expression of the strongest genetic associations in a separate cohort....
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