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Article

Porcine model of hemophilia A.

PloS one - 1 Jan 2012

Kashiwakura Yuji, Mimuro Jun, Onishi Akira, Iwamoto Masaki, Madoiwa Seiji, Fuchimoto Daiichiro, Suzuki Shunichi, Suzuki Misae, Sembon Shoichiro, Ishiwata Akira, Yasumoto Atsushi, Sakata Asuka, Ohmori Tsukasa, Hashimoto Michiko, Yazaki Satoko, Sakata Yoichi

Abstract excerpt

Hemophilia A is a common X chromosome-linked genetic bleeding disorder caused by abnormalities in the coagulation factor VIII gene (F8). Hemophilia A patients suffer from a bleeding diathesis, such as life-threatening bleeding in the brain and harmful bleeding in joints and muscles. Because it could potentially be cured by gene therapy, subhuman animal models have been sought. Current mouse hemophilia A models...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23209578
DOI: 10.1371/journal.pone.0049450
PMCID: PMC3509096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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