Article
Increased incidence of developmental anomalies among descendants of carriers of methylenebisacrylamide-induced balanced reciprocal translocations.
Mutation research - 1 Apr 1990
Rutledge J C, Cain K T, Kyle J, Cornett C V, Cacheiro N L, Witt K, Shelby M D, Generoso W M
Abstract excerpt
N,N'-Methylenebisacrylamide (MBA), a dimer of the monomeric acrylamide, was studied for induction of clastogenic effects in germ cells of male mice. It was found to be effective in inducing dominant-lethal mutations and heritable translocations in maturing sperm. The semisterile translocation carriers and their normal counterparts were used to determine the health impact of transmitted chromosomal rearrangements...
Topics
- Acrylamides
- Animals
- Female
- Gene Rearrangement
- Genes, Dominant
- Genetic Carrier Screening
- Male
- Mice
- Mutagenicity Tests
- Mutation
- Spermatozoa