Article
Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts.
Human molecular genetics - 1 Mar 2013
Vogelaar Ingrid P, Figueiredo Joana, van Rooij Iris A L M, Simões-Correia Joana, van der Post Rachel S, Melo Soraia, Seruca Raquel, Carels Carine E L, Ligtenberg Marjolijn J L, Hoogerbrugge Nicoline
Abstract excerpt
Orofacial clefts (OFC) are among the most common birth defects worldwide. The etiology of non-syndromic OFC is still largely unknown. During embryonic development, the cell adhesion molecule E-cadherin, encoded by CDH1, is highly expressed in the median edge epithelium of the palate. Furthermore,...
Topics
- Animals
- Antigens, CD
- Brain
- CHO Cells
- Cadherins
- Child
- Child, Preschool
- Cleft Lip
- Cleft Palate
- Cricetinae
- Female
- Genetic Predisposition to Disease
- Germ-Line Mutation
- HeLa Cells
- Heterozygote