Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of a trophoblast-like phenotype by hydralazine in the p19 embryonic carcinoma cell line.

Biochimica et biophysica acta - 1 Mar 2013

O'Driscoll Cliona M, Coulter Jonathan B, Bressler Joseph P

Abstract excerpt

Chemicals that affect cellular differentiation through epigenetic mechanisms have potential utility in treating a wide range of diseases. Hydralazine decreases DNA methylation in some cell types but its effect on differentiation has not been well explored. After five days of exposure to hydralazine, P19 embryocarcinoma cells displayed a giant cell morphology and were binucleate, indicative of a trophoblast-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonal Carcinoma Stem Cells
Share to Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Proteins

Share to Neurons

Share to Real-Time Polymerase Chain Reaction

Share to Tretinoin

Share to Trophoblasts

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 23195226
DOI: 10.1016/j.bbamcr.2012.11.012
PMCID: PMC5859318

Genes

TEAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Induction of a trophoblast-like phenotype by hydralazine in the p19 embryonic carcinoma cell line.PMID 23195226Read ↗

Modulation of trophoblast stem cell and giant cell phenotypes: analyses using the Rcho-1 cell model.Semantic proximity Read ↗

Methylation pattern of H19 exon 1 is closely related to preeclampsia and trophoblast abnormalitiesSemantic proximity Read ↗

Hedgehog signaling through GLI1 and GLI2 is required for epithelial–mesenchymal transition in human trophoblastsSemantic proximity Read ↗

Metabolic rewiring underpins human trophoblast inductionSemantic proximity Read ↗

Hydralazine target: From blood vessels to the epigenomeSemantic proximity Read ↗

The seminoma cell line TCam‐2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expressionSemantic proximity Read ↗

The effect of DNA methylation inhibitor 5-Aza-2′-deoxycytidine on human endometrial stromal cellsSemantic proximity Read ↗

Epigenetic Regulation of Human Trophoblastic Cell Migration and InvasionSemantic proximity Read ↗

COMT inhibitor tolcapone represses the migration and invasion of trophoblast and results in preeclampsia-like phenotypes in mice with the modulation of EMT signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.