Article

COMT inhibitor tolcapone represses the migration and invasion of trophoblast and results in preeclampsia-like phenotypes in mice with the modulation of EMT signaling

2023-03-20

Abstract excerpt

Pregnancy in young-onset Parkinson’s disease (YOPD) is rare; however, medication for this condition is critical for maternal and fetal health. Tolcapone is an effective antiparkinsonian drug. However, its safety studies on mothers and fetuses are limited. In this study, we aimed to investigate the effects of tolcapone on the mother and the developing fetus during different stages of gestation. Tolcapone was admini...

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Literature Corpus work: 6a6b1a0c-3345-59c2-a9f9-a9d73205efb5
DOI: 10.1101/2023.03.17.530517

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COMT inhibitor tolcapone represses the migration and invasion of trophoblast and results in preeclampsia-like phenotypes in mice with the modulation of EMT signalingDOI 10.1101/2023.03.17.530517Read

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