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Article

Ohno's "peril of hemizygosity" revisited: gene loss, dosage compensation, and mutation.

Genome biology and evolution - 1 Jan 2013

Hall David W, Wayne Marta L

Abstract excerpt

We explore the evolutionary origins of dosage compensation (DC) in sex chromosomes in the context of metabolic control theory. We consider first the cost of gene loss (hemizygosity) per se in reducing flux, and examine two relationships between flux and fitness (linear and Gaussian) to calculate a fitness cost of hemizygosity. Recognizing that new sex chromosomes are derived from autosomes, we also calculate the...

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Identifiers

PMID: 23193178
DOI: 10.1093/gbe/evs106
PMCID: PMC3607304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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