Article
Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide.
PloS one - 1 Jan 2012
Badsha Farhath, Kain Pinky, Prabhakar Sunil, Sundaram Susinder, Padinjat Raghu, Rodrigues Veronica, Hasan Gaiti
Abstract excerpt
BACKGROUND: Members of the canonical Transient Receptor Potential (TRPC) class of cationic channels function downstream of Gαq and PLCβ in Drosophila photoreceptors for transducing visual stimuli. Gαq has recently been implicated in olfactory sensing of carbon dioxide (CO(2)) and other odorants. Here we investigated the role of PLCβ and TRPC channels for sensing CO(2) in Drosophila. METHODOLOGY/PRINCIPAL...
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