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Article

Apolipoprotein E4 homozygosity predisposes to serum cholesterol elevation during high fat diet.

Arteriosclerosis (Dallas, Tex.) - 1 Jan 2000

Tikkanen M J, Huttunen J K, Ehnholm C, Pietinen P

Abstract excerpt

The hypothesis that apolipoprotein E (apo E)-isoform-related differences in plasma and LDL cholesterol concentrations are due to differential responses to dietary lipids was explored in 110 North Karelian subjects who had previously participated in dietary intervention studies. This was accomplis...

Topics

Adult
Analysis of Variance
Apolipoproteins E
Cholesterol, LDL
Dietary Fats
Female
Homozygote
Humans
Lipoproteins, HDL
Male
Middle Aged
Phenotype
Triglycerides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2317162
DOI: 10.1161/01.atv.10.2.285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2317162-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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