Article
Effects of ezetimibe on lipids and lipoproteins in patients with hypercholesterolemia and different apolipoprotein E genotypes.
Current medical research and opinion - 1 Jul 2007
Mark Laszlo, Dani Gyozo, Fazekas Ozseb, Szüle Olga, Kovacs Hajnalka, Katona Andras
Abstract excerpt
BACKGROUND: The epsilon4 allele of the gene encoding apolipoprotein E (apoE) is associated with elevated serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), as well as an increased risk of coronary heart disease (CHD), greater disease severity, and higher CHD mortality. ApoE epsilon4 allele carriers have also shown reduced lipid and lipoprotein responses to lipid-modifying...
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