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Article

Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in alpha-tropomyosin.

The Journal of biological chemistry - 7 Oct 2005

Chang Audrey N, Harada Keita, Ackerman Michael J, Potter James D

Abstract excerpt

To study the functional consequences of various cardiomyopathic mutations in human cardiac alpha-tropomyosin (Tm), a method of depletion/reconstitution of native Tm and troponin (Tn) complex (Tm-Tn) in cardiac myofibril preparations has been developed. The endogenous Tm-Tn complex was selectively removed from myofibrils and replaced with recombinant wild-type or mutant proteins. Successful depletion and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16043485
DOI: 10.1074/jbc.M505014200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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