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Article

Genetic predisposition to bevacizumab-induced hypertension.

Gynecologic oncology - 1 Dec 2017

Frey Melissa K, Dao Fanny, Olvera Narciso, Konner Jason A, Dickler Maura N, Levine Douglas A

Abstract excerpt

OBJECTIVE: Bevacizumab, a monoclonal antibody to VEGF, has shown efficacy in ovarian, cervical and endometrial cancer in addition to several other solid tumors. Serious side effects include hypertension, proteinuria, bowel perforation, and thrombosis. We tested the hypothesis that genetic variation in hypertension-associated genes is associated with bevacizumab-induced hypertension (BIH). METHODS: Patients with...

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Source

Identifiers

PMID: 28969913
DOI: 10.1016/j.ygyno.2017.09.017

Genes

GRK4
KLKB1
WNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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