Article
Alpha-1 antitrypsin deficiency in patients with chronic hepatitis.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology - 1 Jan 2012
Şımşek Halis, Pinar Aslı, Altinbaş Akif, Alp Alparslan, Balaban Yasemin H, Büyükaşik Yahya, Özcebe Osman, Hasçelık Gülşen, Gedıkoğlu Gökhan, Tatar Gonca
Abstract excerpt
BACKGROUND/AIMS: Alpha-1 antitrypsin deficiency causes accumulation of mutant alpha-1 antitrypsin molecules in hepatocytes, and is attributed to severe liver injury even in heterozygous state. However, there is a question as to whether alpha-1 antitrypsin deficiency is only a cause of liver injury or has a worsening effect on the underlying liver disease. We aimed to determine the role of alpha-1 antitrypsin...
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