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Article

Using the Epigenetic Field Defect to Detect Prostate Cancer in Biopsy Negative Patients

15 Nov 2012

Abstract excerpt

PURPOSE: We determined whether a novel combination of field defect DNA methylation markers could predict the presence of prostate cancer using histologically normal transrectal ultrasound guided biopsy cores. MATERIALS AND METHODS: Methylation was assessed using quantitative Pyrosequencing® in a training set consisting of 65 nontumor and tumor associated prostate tissues from University of Wisconsin. A multiplex...

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PMID: 23159584
DOI: 10.1016/j.juro.2012.11.074

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