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Protein composition and biomechanical properties of in vivo-derived basement membranes

1 Jan 2013

Abstract excerpt

Basement membranes (BMs) evolved together with the first metazoan species approximately 500 million years ago. Main functions of BMs are stabilizing epithelial cell layers and connecting different types of tissues to functional, multicellular organisms. Mutations of BM proteins from worms to humans are either embryonic lethal or result in severe diseases, including muscular dystrophy, blindness, deafness, kidney...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23154404
DOI: 10.4161/cam.22479

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