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Article

Disruption of the KLHL37–N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models

10 Jun 2025

Abstract excerpt

The N-Myc gene MYCN amplification accounts for the most common genetic aberration in neuroblastoma and strongly predicts the aggressive progression and poor clinical prognosis. However, clinically effective therapies that directly target N-Myc activity are limited. N-Myc is a transcription factor, and its stability is tightly controlled by ubiquitination-dependent proteasomal degradation. Here, we discovered that...

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PMID: 40493396
DOI: 10.1172/jci176655

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Related research

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Research trail→

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Disruption of the KLHL37–N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse modelsPMID 40493396Read ↗

MYCN in Neuroblastoma: “Old Wine into New Wineskins”Semantic proximity Read ↗

The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cellsSemantic proximity Read ↗

MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastomaSemantic proximity Read ↗

The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in NeuroblastomaSemantic proximity Read ↗

KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m6A reader YTHDC1 protein degradationSemantic proximity Read ↗

CCNB1IP1 stabilizes MYCN through suppression of Fbxw7-mediated degradation and facilitates the growth of MYCN-amplified neuroblastomaSemantic proximity Read ↗

MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in NeuroblastomaSemantic proximity Read ↗

MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formationSemantic proximity Read ↗

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35Semantic proximity Read ↗

YM155 inhibits neuroblastoma growth through degradation of MYCN: A new role as a USP7 inhibitorSemantic proximity Read ↗

Metastasis in neuroblastoma: the MYCN questionSemantic proximity Read ↗

P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in NeuroblastomaSemantic proximity Read ↗

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