Article
Role of epigenetics in inflammation-associated diseases.
Sub-cellular biochemistry - 1 Jan 2013
Shanmugam Muthu K, Sethi Gautam
Abstract excerpt
There is considerable evidence suggesting that epigenetic mechanisms may mediate development of chronic inflammation by modulating the expression of pro-inflammatory cytokine TNF-α, interleukins, tumor suppressor genes, oncogenes and autocrine and paracrine activation of the transcription factor NF-κB. These molecules are constitutively produced by a variety of cells under chronic inflammatory conditions, which...
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