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Article

The Hedgehog signalling pathway regulates autophagy

13 Nov 2012

Abstract excerpt

Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmental pathways is unclear. Here we show that the Hedgehog signalling pathway inhibits autophagosome synthesis, both in...

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Share to Autophagy in Disease and Therapy
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PMID: 23149744
DOI: 10.1038/ncomms2212

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