Article
Differential expression of the G-protein-coupled formyl Peptide receptor in melanoma associates with aggressive phenotype.
The American Journal of dermatopathology - 1 Apr 2013
Chakravarti Nitin, Peddareddigari Vijay G R, Warneke Carla L, Johnson Marcella M, Overwijk Willem W, Hwu Patrick, Prieto Victor G
Abstract excerpt
Melanoma, due to its metastatic rate, is among the most aggressive forms of skin cancer. Human formyl peptide receptor (FPR) and its variant FPR-like 1 (FPRL1) have been associated with cell migration and invasiveness in neoplasms. We have studied the in situ expression of these receptors in a large series of melanocytic lesions and correlated the expression with clinicopathological features and prognosis. Tissue...
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