Article
Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion.
PloS one - 1 Jan 2012
Oomizu Souichi, Arikawa Tomohiro, Niki Toshiro, Kadowaki Takeshi, Ueno Masaki, Nishi Nozomu, Yamauchi Akira, Hattori Toshio, Masaki Tsutomu, Hirashima Mitsuomi
Abstract excerpt
Galectin-9 (Gal-9), a β-galactoside binding mammalian lectin, regulates immune responses by reducing pro-inflammatory IL-17-producing Th cells (Th17) and increasing anti-inflammatory Foxp3(+) regulatory T cells (Treg) in vitro and in vivo. These functions of Gal-9 are thought to be exerted by binding to receptor molecules on the cell surface. However, Gal-9 lacks a signal peptide for secretion and is...
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