Article
A non-synonymous single nucleotide polymorphism in an OPRM1 splice variant is associated with fentanyl-induced emesis in women undergoing minor gynaecological surgery.
PloS one - 1 Jan 2012
Pang Grace Su Yin, Ithnin Farida, Wong Yin Yee, Wang Jing Bo, Lim Yvonne, Sia Alex Tiong Heng, Lee Caroline Guat Lay
Abstract excerpt
BACKGROUND: Fentanyl-induced emesis (FIE) is a distressing adverse effect in the postoperative setting. The genetic basis of FIE remains largely unknown, therefore, we examined whether it was associated with specific genetic variants of OPRM1, the gene encoding the main receptor target of fentanyl. METHODS: In this prospective case-control study, 193 women undergoing gynaecological surgery under a standardized...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.