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Article

Reg IV Is a Direct Target of Intestinal Transcriptional Factor CDX2 in Gastric Cancer

2 Nov 2012

Abstract excerpt

REG4, which encodes Reg IV protein, is a member of the calcium-dependent lectin superfamily and potent activator of the epidermal growth factor receptor/Akt/activator protein-1 signaling pathway. Several human cancers overexpress Reg IV, and Reg IV expression is associated with intestinal phenotype differentiation. However, regulation of REG4 transcription remains unclear. In the present study, we investigated...

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PMID: 23133598
DOI: 10.1371/journal.pone.0047545

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