Article
Evaluation of interleukin-23 plasma levels in patients with polycythemia vera and essential thrombocythemia.
Cellular immunology - 1 Jan 2000
Gangemi Sebastiano, Allegra Alessandro, Pace Elisabetta, Alonci Andrea, Ferraro Maria, Petrungaro Annamaria, Saitta Salvatore, Gerace Demetrio, Russo Sabina, Penna Giuseppa, Musolino Caterina
Abstract excerpt
Essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis share the same acquired genetic lesion, JAK2V617F. It is believed that cytokines participate in the activation of JAK2V617F. In this study, we analyzed the plasma levels of interleukin (IL)-23, IL-10 and IL-22 in patients with PV and ET. In the same subjects we also performed analysis of the JAK2(V617F) mutation, and evaluated a possible...
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