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Analysis of the global methylation status of human spermatozoa and its association with the tendency of these cells to enter apoptosis

5 Nov 2012

Abstract excerpt

The methylation status of human spermatozoa has been examined in relation to the isopycnic density of these cells and their tendency to spontaneously default to an apoptotic state. DNA methylation was evaluated using three independent procedures: high-pressure liquid chromatography, flow cytometry and immunocytochemistry. All three techniques revealed that poor-quality spermatozoa recovered from the low-density...

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PMID: 23121197
DOI: 10.1111/and.12033

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