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Article

Genetic analysis of the TBX3 gene promoter in ventricular septal defects.

Gene - 10 Jan 2013

Chen Dongfeng, Qiao Yanli, Meng Haihong, Pang Shuchao, Huang Wenhui, Zhang Hongyu, Yan Bo

Abstract excerpt

Congenital heart disease (CHD) is the most common birth defect in humans. Genetic causes and underlying molecular mechanisms for CHD remain largely unknown. T-box transcription factor 3 (TBX3) plays a critical role in the developing heart in a dose-dependent manner. TBX3 represses chamber myocardial gene expression. Mutations in TBX3 gene have been associated to ulnar-mammary syndrome with multiple developmental...

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Topics

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Share to Heart Septal Defects, Ventricular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutagenesis, Insertional

Share to Promoter Regions, Genetic

Share to Sequence Deletion

Share to T-Box Domain Proteins

Source

Identifiers

PMID: 23116943
DOI: 10.1016/j.gene.2012.10.066

Genes

TBX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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