Article
Blastic transformation in essential thrombocythemia. In vitro differentiation of blast cells into granulocytic, erythroid, and megakaryocytic lineages.
Cancer - 1 Apr 1990
Kimura A, Fujimoto T, Inada T, Imamura N, Oguma N, Kajihara H, Mtasiwa D M, Katoh O, Fujimura K, Kuramoto A
Abstract excerpt
A 57-year-old man with essential thrombocythemia (ET) developed myelofibrosis, that progressed to a blastic transformation state. The characteristics of the blastic cells were serially studied both morphologically and phenotypically as well as in cell culture. The blastic cells that were first detected in peripheral blood had features of myeloid stem cells with slight differentiation toward megakaryocytic...
Topics
- Blast Crisis
- Cell Differentiation
- Cytoplasm
- Erythrocytes
- Granulocytes
- Humans
- Male
- Megakaryocytes
- Middle Aged
- Phenotype
- Thrombocythemia, Essential