Article
A quantitative genetic and epigenetic model of complex traits.
BMC bioinformatics - 26 Oct 2012
Wang Zhong, Wang Zuoheng, Wang Jianxin, Sui Yihan, Zhang Jian, Liao Duanping, Wu Rongling
Abstract excerpt
BACKGROUND: Despite our increasing recognition of the mechanisms that specify and propagate epigenetic states of gene expression, the pattern of how epigenetic modifications contribute to the overall genetic variation of a phenotypic trait remains largely elusive. RESULTS: We construct a quantitative model to explore the effect of epigenetic modifications that occur at specific rates on the genome. This model,...
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