Population dynamics of a meiotic/mitotic expansion model for the fragile X syndrome.

Article

Population dynamics of a meiotic/mitotic expansion model for the fragile X syndrome.

American journal of human genetics - 1 Dec 1995

Ashley A E, Sherman S L

Abstract excerpt

A model to explain the mutational process and population dynamics of the fragile X syndrome is presented. The mutational mechanism was assumed to be a multipathway, multistep process. Expansion of CGG repeats was based on an underlying biological process and was assumed to occur at two time point...

Topics

Female
Fragile X Syndrome
Heterozygote
Humans
Male
Meiosis
Mitosis
Models, Genetic
Mutation
Population Dynamics
Repetitive Sequences, Nucleic Acid

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