Article
Fortuitous description of haemoglobin A2' [δ16 (A13) Gly→Arg (GGC→CGC)] in a Tunisian family: study of the molecular defect and its origin.
Annales de biologie clinique - 1 Jan 2000
Sahli Chaima Abdelhafidh, Gritli Sami, Dabboubi Rym, Omar Souheil, Siala Hajer, Kaabachi Naziha, Bibi Amina, Messaoud Taieb
Abstract excerpt
The most common inherited haemoglobin disorders encountered in Tunisia are β-thalassemia and sickle cell disease, which result from mutations in the β-globin gene. Few studies focused on δ-globin gene variations responsible for δ-thalassemia or HbA2 variants. HbA2' [δ16 (A13) Gly→Arg (GGC→CGC)] is a δ-chain variant that has been identified in several populations of African origin. We report herein for the first...
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