Article
Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following insecticide selection in the field mosquitoes.
PloS one - 1 Jan 2012
Xu Qiang, Zhang Lee, Li Ting, Zhang Lan, He Lin, Dong Ke, Liu Nannan
Abstract excerpt
Target site insensitivity resulting from point mutations within the voltage-gated sodium channel of the insect nervous system is known to be of primary importance in the development of resistance to pyrethroid insecticides. This study shifts current research paradigms by conducting, for the first time, a global analysis of all the naturally occurring mutations, both nonsynonymous and synonymous mutations, as well...
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