Article
Functional haplotypes of the hTERT gene, leukocyte telomere length shortening, and the risk of peripheral arterial disease.
PloS one - 1 Jan 2012
Zhang Weili, Chen Yu, Yang Xiaomin, Fan Jingyao, Mi Xuenan, Wang Jizheng, Zhang Channa, Hu Frank B, Hui Rutai
Abstract excerpt
BACKGROUND: The development of peripheral arterial disease (PAD) is heterogeneous even in the presence of similar risk factors. Our aim was to determine whether inter-individual differences in leukocyte telomere length contribute to the susceptibility of PAD. METHODS: A total of 485 patients with PAD (defined by the ankle-brachial index) and 970 age- and gender-matched controls were recruited from seven rural...
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