Article
Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas.
Developmental biology - 1 Jan 2013
Balakrishnan Ashwini, Chaillet J Richard
Abstract excerpt
Teratomas are a unique class of tumors composed of ecto-, meso- and endodermal tissues, all foreign to the site of origin. In humans, the most common teratoma is the ovarian teratoma. Not much is known about the molecular and genetic etiologies of these tumors. Female carriers of the Tgkd transgene are highly susceptible to developing teratomas. Ovaries of Tgkd/+ hemizygous female mice exhibit defects in...
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