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Article

Mutation of crp mediates Serratia marcescens serralysin and global secreted protein production.

Research in microbiology - 1 Jan 2013

Shanks Robert M Q, Stella Nicholas A, Arena Kristin E, Fender James E

Abstract excerpt

The bacterial species Serratia marcescens secretes both beneficial and cytotoxic proteins. Here we report that a crp mutant exhibited elevated secreted protease activity. A genetic screen revealed that the gene coding for the metalloprotease serralysin was necessary for the elevated proteolysis, and this was confirmed by western blot analysis. Proteomic analysis of secreted proteins corroborated increased...

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Identifiers

PMID: 23072819
DOI: 10.1016/j.resmic.2012.10.006
PMCID: PMC3534799

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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