Article
Functional divergence of gene duplicates through ectopic recombination.
EMBO reports - 1 Dec 2012
Christiaens Joaquin F, Van Mulders Sebastiaan E, Duitama Jorge, Brown Chris A, Ghequire Maarten G, De Meester Luc, Michiels Jan, Wenseleers Tom, Voordeckers Karin, Verstrepen Kevin J
Abstract excerpt
Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub- or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell-surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO...
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