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Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization.

FEBS letters - 16 Nov 2012

Han Seung Yeop, Lee Minjung, Hong Yoon Ki, Hwang Soojin, Choi Gahee, Suh Yoon Seok, Park Seung Hwan, Lee Soojin, Lee Sang-Hee, Chung Jongkyeong, Baek Sung Hee, Cho Kyoung Sang

Abstract excerpt

The metastasis suppressor KAI1/CD82 has been implicated in various cellular processes; however, its function in development is not fully understood. Here, we generated and characterized mutants of Tsp66E and Tsp74F, which are Drosophila homologues of KAI1/CD82 and Tspan11, respectively. These mutants exhibited egg elongation defects along with disturbed integrin localization and actin polarity. Moreover, the...

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PMID: 23068610
DOI: 10.1016/j.febslet.2012.09.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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